Actraphane 20/80
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Mixtard 20,Penmix 20
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.

Novo Nordisk's brand name for its 20% R/neutral and 80% NPH/isophane crystal[2] insulin[3] which is intermediate-acting.

Another comparable insulin, also Novo-made was Mixtard 20[4][5][6][7]. Eli Lilly produced a comparable insulin called Humulin M2[8]; it was discontinued in the EU & UK in July, 2004.


  1. Humulin M2 Discontinued July 2004
  2. EMEA Scientific Discussion Actraphane
  3. Humulin 20/80-NPH;R Human Insulin
  4. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Mixtard 20
  5. Insulins & Mixtures
  6. EMEA Scientific Discussion-Mixtard
  7. Prescribing Novo Insulins
  8. Lilly EU/UK Product Names & Time Activity Profiles

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