R,Neutral by Novo Nordisk
short-acting r-DNA/GE/GM
U100 none
Line Novo
Also known as Novolin R
Similar to  
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h[1]
Use and Handling
Type soluble
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
  • protect from light and heat
  • Do Not Freeze
  • May be used intravenously

Novo Nordisk's brand of fast-acting insulin[2][3][4], known as Novolin R in North America.

Comparable insulins made by others are: Humulin R[5] and Humulin S[6][7][8] by Eli Lilly, and Insuman Rapid[9][10] by Aventis.

Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed[11]


  1. Insulins-North American Veterinary Conference
  2. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Actrapid
  3. EMEA Scientific Discussion-Actrapid
  4. Prescribing Novo Insulins
  5. Humulin R Regular Human Insulin
  6. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin S
  7. Humulin S Prescribing Information
  8. Lilly EU/UK Product Sheet & Time Activity Profiles
  9. Electronic medicines Compendium (EMC) UK-Patient Information Leaflet-InsumanRapid
  10. Prescribing Insuman Insulins
  11. FDA-Humulin R