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Diabetes in Pets

BCP PZI

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BCP PZIEdit

BCP PZI
PZI by BCP Veterinary Pharmacy
long-acting Bovine
U100/U50/U40 protamine
Line N/A
Also known as beef PZI
Similar to  
Action in cats  
  • onset 2-5h,
  • peak 12-24h
  • duration: maximum 36h
Action in dogs  
  • onset 8-20h,
  • peak Xh,
  • duration Xh rarely used[1]
Use and Handling
Type cloudy
Shelf Life 6 months
When opened XX days
In pen N/A
Notes  


What it is. BCP PZI is a bovine-origin PZI-based compounded insulin. Because it's beef based, its amino acid chain is almost the same as that of a cat, so it's especially well-matched to cats. BCP Veterinary Pharmacy in Houston, TX, USA, manufactures and is the sole source supplier for BCP PZI. BCP PZI is commonly used in diabetic cats in the U.S.

Generally, depending on an individual cat’s reaction to the insulin and the dosage, BCP PZI will lower blood glucose levels for 10 to 14 hours with a peak in the +6 to +8 timeframe. However, some cats experience shorter or longer duration and earlier or later peaks.

Felineinsulin8

Feline insulin compared with Bovine, Human, & Porcine versions. Up to 4 amino acids differ. The closest match is bovine with only one amino acid difference; the lease close is human with four amino acid differences.


Like other insulins, BCP PZI is normally administered twice a day.

How to get it. To obtain BCP PZI, your veterinarian calls or faxes a prescription (a script) to the phone numbers shown on the BCP Internet site (see the source information below). After the script is placed, you call BCP with a credit card number and BCP ships the insulin to you overnight for delivery Tuesday through Friday. If you want the insulin left without a delivery signature, you should ask BCP for that.

Strength and cost: Your vet can order BCP PZI in a U40, U50, or U100 formulation. Some BCP PZI users have their vets order the U40 or U50 strengths and they convert units[2] to administer it in a U100 syringe. BCP PZI is available in 5ml and 10ml vials. A recent price of a 10ml 40U bottle was $29, plus $11 shipping ($40 total).

Shelf life: 6 months.

Handling: You should refrigerate BCP PZI when it is not in use. If you happen to leave it out for one night, most report no problems.

No Combining For PZI

Protamine Zinc PZI[3] insulin cannot be combined with other insulins, due to the amount of protamine in the insulin's formula[4][5].


Further ReadingEdit

Wikicat3

ReferencesEdit

  1. Insulins-North American Veterinary Conference-2005
  2. Using U40 Insulin in U100 Syringes: Conversion Information
  3. Excess Protamine in Protamine Zinc Insulin Formula
  4. Comparison of Injection Techniques for Soluble and Protamine Zinc Insulins in Diabetes Mellitus PubMed-Practitioner-1975
  5. NHS UK-Protamine Zinc Insulin (PZI) Binds to Soluble Insulin in Same Syringe

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