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Diabetes in Pets

Porcine

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Iletin II R-pork R/Neutral insulin.

Porcine insulin (from pigs) is an exact amino acid match to that of dogs[1].

It differs from human insulin in one position. At B #30 on the B insulin chain, dogs and pigs have Alanine, while people have Threonine. It differs from bovine in two positions, both on the A insulin chain: pigs have Threonine at A #8 while cows have Alanine. At the #10 position on the A insulin chain, pigs have Isoleucine--cows have Valine.

Cats, like cows, both have Alanine in the A #8 and Valine in the A #10 positions. But cats have Histidine in the A #18 position--pork or pig insulin has Asparagine--making 3 amino acid differences between porcine insulin and feline[2].

Though this shows CP Pharma's Hypurin pork insulins[3], this information would also apply to Novo's Pork Insulatard, Pork Actrapid, and Pork Mixtard 30[4][5]. They can also be applied to compare these to Lilly's former Iletin II R and Iletin II NPH. The study at the link below found that pork R/Neutral is suitable to be used intravenously in cats[6]

Porcineinsulin8

Porcine insulin compared to Bovine, Human, and Feline versions. Up to three amino acids differ. Porcine and canine insulin are identical[7].

These insulins are natural and entirely or partly derived from pork (pig) sources. Only Iletin I R shown on the list below was a mixture of bovine and porcine insulins; it was composed primarily of beef (apx. 85/90%).

This means that they are identical to canine natural insulin, and a bit closer to feline than human insulin is.

Many humans also prefer porcine-based insulins, which are claimed by some to give a clearer warning of impending low blood sugar than the comparable human GE and analog insulins.

Porcine InsulinsEdit

Porcine Insulins

Short Acting

Soluble

R/Neutral

Hypurin Porcine Neutral
Hypurin Pork Regular

R/Neutral

Pork Actrapid

R/Neutral

Iletin II R
(No longer produced.)

Short Acting

Cloudy

Semilente

Novo Semilente MC

Intermediate Acting

Non-Mixed

NPH/isophane

Hypurin Porcine Isophane
Hypurin Pork NPH

NPH/isophane

Pork Insulatard

NPH/isophane

Iletin II NPH
(No longer produced.)

Lente

Caninsulin, Vetsulin

Lente

Monotard Pork
(No longer produced.)

Lente

Iletin II Lente
(No longer produced.)

Intermediate Acting

Mixed

R/Neutral 30%
NPH/isophane 70%

Hypurin Porcine 30/70 Mix

R/Neutral 30%
NPH/isophane 70%

Pork Mixtard 30

See also bovine insulins.

Further ReadingEdit

Case StudiesEdit

Wikicat3


Wikidog3


ReferencesEdit

  1. Intervet-Caninsulin-Product Information
  2. BCP Veterinary Pharmacy-Bovine PZI Insulin
  3. Prescribing Porcine Insulins
  4. Prescribing Novo Animal Insulins
  5. Response To Withdrawal of Novo Porcine Insulins-CP/Wockhardt UK
  6. Pharmacology of a U40 Porcine Lente Insulin Preparation in Diabetic Cats-Journal of Feline Medicine & Surgery-Rand & Martin-2001
  7. Intervet-Caninsulin-Product Information

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