Another name for Eli Lilly's 25% insulin lispro and 75% insulin lispro protamine suspension analog insulin[1]. The 75% fraction that is NPL (Neutral Protamine Lispro)[2] is a suspension of crystals formed by combining insulin lispro and protamine. It's also called Humalog 75/25.

A study of dogs from 1993-1994 using various fractions of Humalog mixes against human NPH/isophane insulin found only minor differences in the use of Humalog Mix as opposed to NPH/isophane insulin[3].


  1. Humalog 75/25-Insulin Lispro Protamine; Insulin Lispro
  2. FDA-Humalog 75/25
  3. US-FDA Humalog Pharmacology Review-Pages 5 & 6

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