Humulin I

From Diabetes in Pets

Use and Handling
Humulin I
NPH/Isophane by Eli Lilly
intermediate-acting	r-DNA/GE/GM
U100	Isophane
Line	Humulin
Also known as	Humulin N
Similar to	Novolin N, Insulatard, Protaphane Insuman Basal ReliOn/Novolin NPH
Action in cats	onset 1-2h, sharp peak 4-6h, duration 8-12h^[1]^[2]
Action in dogs	onset 0.5-3h, peak 2-10h^[3], duration 4-24h
Type	cloudy
Shelf Life	18 months
When opened	28 days room temp.
In pen	28 days room temp.
Notes	roll protect from light Do Not Freeze Do not use if product does not re-suspend Do not use intravenously

This is the Euro name for Lilly's isophane-suspension insulin^[4]--the "I" an abbreviation for isophane^[5]^[6].

Lilly makes the same insulin known as Humulin N^[7] in North America^[8].

Like all other isophane/protamine suspended insulins, it is a crystalline suspension with protamine.

[edit] Technical details

This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.

These times seem to be similar in dogs, but considerably compressed in cats, possibly because of cats' faster metabolism.

Cats seem instead to experience a 1-2 hour onset, a peak action of 4-6 hours, and a total duration of 8-12 hours maximum, according to user surveys on Felinediabetes.com.

Novo Nordisk also has their Novolin N, Protaphane and Insulatard^[9]^[10]^[11]^[12] while Aventis has their Insuman Basal^[13]^[14].

[edit] Further Reading

How to use NPH insulins on cats by Kimber & Bunny and the FDMB

[edit] References

[0] Insulins-North American Veterinary Conference-2005

[1] Selecting an Insulin for Treatment of Diabetes Mellitus in Dogs & Cats-Nelson-OSU Endocrinology Symposium 2006-Page 41

[2] Insulins-North American Veterinary Conference-2005

[3] Humulin I Prescribing Information

[4] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin I

[5] Lilly UK Product Names & Time Activity Profiles

[6] Humulin N-NPH/Isophane Human Insulin Remedyfind.com

[7] FDA--Humulin N

[8] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insulatard

[9] EMEA Scientific Discussion-Insulatard

[10] Prescribing Novo Insulins

[11] EMEA Scientific Discussion-Protaphane

[12] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Basal

[13] Insuman Prescribing Information

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