FANDOM


Humulin I
NPH/Isophane by Eli Lilly
intermediate-acting r-DNA/GE/GM
U100 Isophane
Line Humulin
Also known as Humulin N
Similar to  
Action in cats  
  • onset 1-2h,
  • sharp peak 4-6h,
  • duration 8-12h[1][2]
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h[3],
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 18 months
When opened 28 days room temp.
In pen 28 days room temp.
Notes  

This is the Euro name for Lilly's isophane-suspension insulin[4]--the "I" an abbreviation for isophane[5][6].

Lilly makes the same insulin known as Humulin N[7] in North America[8].

Like all other isophane/protamine suspended insulins, it is a crystalline suspension with protamine.

Technical detailsEdit

This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.

These times seem to be similar in dogs, but considerably compressed in cats, possibly because of cats' faster metabolism.

Cats seem instead to experience a 1-2 hour onset, a peak action of 4-6 hours, and a total duration of 8-12 hours maximum, according to user surveys on Felinediabetes.com.

Novo Nordisk also has their Novolin N, Protaphane and Insulatard[9][10][11][12] while Aventis has their Insuman Basal[13][14].

Further ReadingEdit

Wikicat3

ReferencesEdit

  1. Insulins-North American Veterinary Conference-2005
  2. Selecting an Insulin for Treatment of Diabetes Mellitus in Dogs & Cats-Nelson-OSU Endocrinology Symposium 2006-Page 41
  3. Insulins-North American Veterinary Conference-2005
  4. Humulin I Prescribing Information
  5. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Humulin I
  6. Lilly UK Product Names & Time Activity Profiles
  7. Humulin N-NPH/Isophane Human Insulin Remedyfind.com
  8. FDA--Humulin N
  9. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insulatard
  10. EMEA Scientific Discussion-Insulatard
  11. Prescribing Novo Insulins
  12. EMEA Scientific Discussion-Protaphane
  13. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Basal
  14. Insuman Prescribing Information

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.