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Hypurin Bovine Lente

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Hypurin Bovine Lente
Lente by CP Pharma
intermediate-acting Bovine
U100 Zinc
Line Hypurin
Also known as beef lente
Similar to  
Action in cats  
  • onset 2-3h[1],
  • peak 6-12h
  • duration: maximum 18h
Action in dogs  
  • onset 2-5h,
  • peak 12-24h,
  • duration: maximum 36h
Use and Handling
Type cloudy
Shelf Life 36 months
When opened 28 days
In pen N/A
Notes  

Hypurin Bovine Lente is a beef-based Lente insulin made by CP Pharma[2][3][4][5].

It is comparable to Insuvet's Insuvet Lente and to the discontinued Lilly Iletin I Lente.

What Lente Is NotEdit

No Lente-type insulin regardless of species can contain any NPH/isophane insulin[6] or any R/Neutral insulin[7].

Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral[8].

The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect[9][10].

Combining Lente Family InsulinsEdit

Insulin manufacturers[11] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins[12][13][14][15].

None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with[16] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action[17].

Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins[18].

In the UK, Best Pet Pharmacy has it in stock.

ReferencesEdit

  1. Petsulin Lente Page 9 Note Re: shorter feline duration
  2. Hypurin Bovine Lente Patient Information
  3. Electronic Medicines Compendium (EMC) UK-Hypurin Bovine Lente
  4. Prescribing Bovine Insulin
  5. Hypurin Bovine Lente Lente Beef Insulin Remedyfind.com
  6. Combining Lente-type Insulins with Phenol-Preserved Insulins
  7. Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect
  8. Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination
  9. Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente Diabetes Care-1980
    Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins
  10. Resource Guide 2005-American Diabetes Association
  11. Insulin Producers vs Doctors Re:Combining R/Neutral & Lente-type Insulins
  12. Availability of Soluble (R/Neutral) Insulin in Mixed Preparations of Crystalline (Lente) & Ultralente GE Insulins-Clinical Therapeutics-1991
  13. Absorption Kinetics & Action Profiles-Single Subcutaneous Administration of Human Soluble (R/Neutral) & Lente Insulin-Diabetes Care-1987
  14. Delayed Onset of Action of Soluble (R/Neutral) Insulin After Premixing With Lente Insulin Diabetes Research & Clinical Practice-1983
  15. RxEd.org-Insulin Therapy-Mixing Precautions
  16. Phenol Preservatives & Lente-type Insulins--A Bad Combination
  17. RxEd.org-Insulin Therapy-Mixing Precautions
  18. RxEd.org-Insulin Therapy-Mixing Precautions

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