Mixtard 20

From Diabetes in Pets

Mixtard 20
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting	r-DNA/GE/GM
U100	isophane
Line	Novo
Also known as	Actraphane 20/80, Penmix 20[1]
Similar to	Humulin M2
Action in cats	onset Xh, peak Xh duration Xh
Action in dogs	onset 0.5-3h, peak 2-10h, duration 4-24h
Use and Handling
Type	cloudy
Shelf Life	30 months
When opened	6 weeks room temp.
In pen	6 weeks room temp.
Notes	protect from light and heat Do Not Freeze Do not use if product does not re-suspend Roll Do not use intravenously Do not refrigerate in use pens/cartridges.

A mixed, intermediate-acting insulin^[2][3] made by Novo Nordisk containing 20% R/neutral insulin and 80% NPH/isophane insulin crystals^[4][5].

Comparable product is also made by Novo: Actraphane 20/80^[6].

Eli Lilly once produced a similar insulin in the EU & UK called Humulin M2^[7]; it was discontinued in July 2004^[8].

Mixtard 20 was discontinued December 31, 2007.^[9][10]

[edit] References

1. ↑ Medsafe NZ Penmix 20
2. ↑ Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 20
3. ↑ Prescribing Novo Insulins
4. ↑ EMEA Scientific Discussion-Mixtard
5. ↑ Humulin 20/80-NPH;R Human Insulin Remedyfind.com
6. ↑ EMEA Scientific Discussion-Actraphane
7. ↑ Lilly Product Sheet & Time Activity Profiles
8. ↑ Withdrawal of Humulin M2 July 2004
9. ↑ Insulin Discontinuations-UK
10. ↑ Chart of Discontinued Novo Human Insulins