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Diabetes in Pets

Mixtard 20

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Mixtard 20
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Actraphane 20/80, Penmix 20[1]
Similar to Humulin M2
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
Notes  
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate in use pens/cartridges.

A mixed, intermediate-acting insulin[2][3] made by Novo Nordisk containing 20% R/neutral insulin and 80% NPH/isophane insulin crystals[4][5].

Comparable product is also made by Novo: Actraphane 20/80[6].

Eli Lilly once produced a similar insulin in the EU & UK called Humulin M2[7]; it was discontinued in July 2004[8].

Mixtard 20 was discontinued December 31, 2007.[9][10]

ReferencesEdit

  1. Medsafe NZ Penmix 20
  2. Electronic Medicines Compendium (EMC) UK-Patient Information-Mixtard 20
  3. Prescribing Novo Insulins
  4. EMEA Scientific Discussion-Mixtard
  5. Humulin 20/80-NPH;R Human Insulin Remedyfind.com
  6. EMEA Scientific Discussion-Actraphane
  7. Lilly Product Sheet & Time Activity Profiles
  8. Withdrawal of Humulin M2 July 2004
  9. Insulin Discontinuations-UK
  10. Chart of Discontinued Novo Human Insulins

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