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Monotard Pork
Lente by Novo Nordisk
intermediate-acting Porcine
U100 Zinc
Line Novo
Also known as N/A
Similar to  :
Action in cats  
  • onset Xh,
  • peak Xh
  • duration: Xh
Action in dogs  
  • onset <1h,
  • peak 4-8h,
  • duration 14-24h
Use and Handling
Type cloudy
Shelf Life 24 months
When opened 28 days
In pen N/A
Notes  
  • protect from light and heat
  • store at 2-8C
  • Do not use if product does not re-suspend
  • Roll
  • See Caninsulin/Vetsulin for current handling notes on pork lente insulin.

Monotard Pork was a U100, 100% porcine insulin made by Novo Nordisk. It was an intermediate-acting, lente-type.

Eli Lilly also made a comparable pork lente insulin, Iletin II Lente[1][2].

As the other Lente insulins[3], it was a suspension of crystalline (ultralente) and amorphous (semilente) insulin in a ratio of 7 crystalline parts to 3 amorphous parts.

Monotard Pork was also identical to Caninsulin[4][5]/Vetsulin with the only exception being its strength: Pork Monotard was U100 strength, while Caninsulin/Vetsulin is U40.

What Lente Is NotEdit

No Lente-type insulin regardless of species can contain any NPH/isophane insulin[6] or any R/Neutral insulin[7].

Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral[8].

The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect[9][10][11].

Combining Lente Family InsulinsEdit

Insulin manufacturers[12] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins[13][14][15][16].

None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with[17] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action[18].

Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins[19].


ReferencesEdit

  1. Drugs.com-Copy of Iletin II Lente Patient Information Leaflet
  2. US-FDA Iletin II Lente Discontinuation Material 2003
  3. EMEA Scientific Discussion-Monotard
  4. Horn Mitten Study-Refers to the Church Study Equating Caninsulin with Novo's old Pork Monotard
  5. Australian Veterinary Journal-More Re: Caninsulin Being Equivalent to Pork Monotard
  6. Combining Lente-type Insulins with Phenol-Preserved Insulins
  7. Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect
  8. Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination
  9. Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente Diabetes Care-1980
    Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins
  10. Solubility Changes on Mixing Short- and Long-acting Insulin Preparations-South African Medical Journal-1988
  11. Resource Guide 2005-American Diabetes Association
  12. Insulin Producers vs Doctors Re:Combining R/Neutral & Lente-type Insulins
  13. Availability of Soluble (R/Neutral) Insulin in Mixed Preparations of Crystalline (Lente) & Ultralente GE Insulins-Clinical Therapeutics-1991
  14. Absorption Kinetics & Action Profiles-Single Subcutaneous Administration of Human Soluble (R/Neutral) & Lente Insulin-Diabetes Care-1987
  15. Delayed Onset of Action of Soluble (R/Neutral) Insulin After Premixing With Lente Insulin Diabetes Research & Clinical Practice-1983
  16. RxEd.org-Insulin Therapy-Mixing Precautions
  17. Phenol Preservatives & Lente-type Insulins--A Bad Combination
  18. RxEd.org-Insulin Therapy-Mixing Precautions
  19. RxEd.org-Insulin Therapy-Mixing Precautions

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