Penmix 10[1]
R/Neutral/NPH/Isophane by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novo
Also known as Mixtard 10[2]
Similar to None
Action in cats  
  • onset Xh,
  • peak Xh
  • duration Xh
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate in use pens/cartridges

This is an intermediate-acting, mixed insulin[3][4] consisting of 10% R/neutral insulin and 90% NPH/isophane insulin crystals[5][6] made by Novo Nordisk.

It is similar to Mixtard 10 which was was discontinued December 31, 2007.[7][8]


  1. Medsafe NZ Penmix 10
  2. Electronic Medicines Compendium (EMC) UK-Patient information-Mixtard 10
  3. Electronic Medicines Compendium (EMC) UK-Patient information-Mixtard 10
  4. Prescribing Novo Insulins
  5. EMEA Scientific Discussion-Mixtard
  6. Humulin 10/90-NPH;R Human Insulin
  7. Insulin discontinuations-UK
  8. Chart of Discontinued Novo Human Insulins

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